TY - JOUR
AB - Pediatr Nephrol (2005) 20:C7– C11 © IPNA 2005 DOI 10.1007/s00467-005-1820-1 ABSTRACTS IPNA Seventh Symposium on Growth and Development in Children with Chronic Kidney Disease: The Molecular Basis of Skeletal Growth 1–3 April 2004, Heidelberg, Germany P01 P02 SIGNALING PATHWAYS LEADING TO THE REGULATION MECHANISMS OF MITOGEN-ACTIVATED PROTEIN OF PROLIFERATION AND DIFFERENTIATION OF KINASE INHIBITION BY PTH IN OSTEOBLASTS GROWTH PLATE CHONDROCYTES BY IGF-I M Hömme, CP Schmitt, O Mehls, F Schaefer 1 1 1 2 1 University Children’s Hospital, Division of Pediatric Nephrology, INF 150, S Ciarmatori , A Haarmann , D Kiepe , A Spagnoli , B Tönshoff Heidelberg, Germany Division of Pediatric Nephrology, University Children's Hospital Heidelberg, Germany; Department of Pediatrics, Vanderbilt University Medical Center, PTH dose-dependently inhibits osteoblast proliferation and the activation Nashville, USA of p42/44 MAPK, the major stimulatory pathway. Furthermore, PTH Because IGF-I is an important chondrocyte growth factor, we sought to inhibits the stress-induced c-Jun-NH -terminal kinase (JNK), another examine the intracellular mechanisms by which it exerts two of its pivotal member of the MAP kinase family. Recently, it has been shown that effects, stimulation of proliferation and differentiation. We used the mes- osteoblasts express MKP-1, a dual-specific phosphatase which binds to and 
TI - IPNA Seventh Symposium on Growth and Development in Children with Chronic Kidney Disease: The Molecular Basis of Skeletal Growth, 1 - 3 April 2004, Heidelberg, Germany
JF - Pediatric Nephrology
DO - 10.1007/s00467-005-1820-1
DA - 2005-02-12
UR - https://www.deepdyve.com/lp/springer-journals/ipna-seventh-symposium-on-growth-and-development-in-children-with-JjmgVIEYKP
SP - C7
EP - C11
VL - 20
IS - 3
DP - DeepDyve
ER -