TY - JOUR
AU - Lippmann, W
AB - COMMUNICATIONS, J. Pharm. Pharmacol. 1979, 31 : 47 Effects of chlorine substituents on the benzene rings of an analogue of the antipsychotic drug butaclamol on the interaction with dopamine and muscarinic receptors in rat brain T A. PUGSLEY, W. LIPPMANN*, Biochemical Pharmacology Department, Ayerst Laboratories, P.O. Box 6115, Montreal, Quebec, Canada H3C 3JI Clozapine has been reported to inhibit psychotic reac- to inhibit the binding of [8H]haloperidol [(G) (sp. act. tions in man without producing extrapyramidal side 13-5 Ci mmol-l, New England Nuclear)] to a rat brain effects (Angst et al 1971). In animals, clozapine differs striatal membrane homogenate employing the method from classical neuroleptic drugs in that it does not pro- of Burt et al (1976). A rat brain striatal homogenate duce catalepsy, exhibits only weak antagonism of (11.1 mg protein per incubation tube) and the test apomorphine and amphetamine stereotype behaviour, agents were incubated at 37" C for 10 min with 2 nM and elevates striatal homovanillic acid (HVA) con- [3H]haloperidol in 50 mM tris-HCI buffer, pH 7.1, centration only at high doses (Stille et al 1971). The containing 0.1% ascorbic acid, 10 p~ pargyline and basis for the difference between clozapine and other 1976). The incubation 
TI - Effects of chlorine substituents on the benzene rings of an analogue of the antipsychotic drug butaclamol on the interaction with dopamine and muscarinic receptors in rat brain
JO - Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science
DO - 10.1111/j.2042-7158.1979.tb13422.x
DA - 1979-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/effects-of-chlorine-substituents-on-the-benzene-rings-of-an-analogue-JQNcM0fdqP
SP - 47
EP - 49
VL - 31
IS - 1
DP - DeepDyve
ER -