TY - JOUR
AU - Jaggi, Amteshwar Singh
AB - Abstract Background: Aldose reductase is primarily involved in development of long-term diabetic complications due to increased polyol pathway activity. The synthetic aldose reductase inhibitors are not very successful clinically. Therefore, the natural sources may be exploited for safer and effective aldose reductase inhibitors. Methods: In the present study, the aldose reductase inhibitory potential of hydroalcoholic and alkaloidal extracts of Piper nigrum , Murraya koenigii , Argemone mexicana , and Nelumbo nucifera was evaluated. The hydroalcoholic and alkaloidal extracts of the selected plants were prepared. The different concentrations of hydroalcoholic and alkaloidal extracts of these plants were evaluated for their goat lens aldose reductase inhibitory activity using dl -glyceraldehyde as substrate. The aldose reductase inhibitory potential of extracts was assessed in terms of their IC 50 value. Results: Amongst the hydroalcoholic extracts, the highest aldose reductase inhibitory activity was shown by P. nigrum (IC 50 value 35.64±2.7 μg/mL) followed by M. koenigii (IC 50 value 45.67±2.57 μg/mL), A. mexicana (IC 50 value 56.66±1.30 μg/mL), and N. nucifera (IC 50 value 59.78±1.32 μg/mL). Among the alkaloidal extracts, highest inhibitory activity was shown by A. mexicana (IC 50 value 25.67±1.25 μg/mL), followed by N. nucifera (IC 50 value 28.82±1.85 μg/mL), P. nigrum (IC 50 value 30.21±1.63 μg/mL), and M. koenigii (IC 50 value 35.66±1.64 μg/mL). Conclusions: It may be concluded that the alkaloidal extracts of these plants possess potent aldose reductase inhibitory activity and may be therapeutically exploited in diabetes-related complications associated with increased activity of aldose reductase.
TI - Evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of Piper nigrum, Murraya koenigii, Argemone mexicana , and Nelumbo nucifera
JF - Journal of Basic and Clinical Physiology and Pharmacology
DO - 10.1515/jbcpp-2013-0071
DA - 2014-05-01
UR - https://www.deepdyve.com/lp/de-gruyter/evaluation-of-in-vitro-aldose-reductase-inhibitory-potential-of-JHoN0hT16c
SP - 255
VL - 25
IS - 2
DP - DeepDyve
ER -