TY - JOUR
AU - Murray, Henry W.
AB - Abstract If one prepares a list of the diverse microorganisms that require an intact T-cell-dependent immune response for control or eradication, and compares this with a list of pathogens that regularly infect patients with acquired immunodeficiency syndrome (AIDS), the two are virtually superimposable. This observation is not particularly surprising (and, indeed, seems readily predictable) given the uniform and profound impairment in the AIDS patient's T-cell-mediated immune responses. There is, however, one well-known intracellular opportunistic pathogen, Listeria monocytogenes, which rarely infects AIDS patients1; this finding is curious and remains unexplained. Because it was used to originally delineate the basic mechanisms of cell-mediated immunity, L monocytogenes maintains a special niche in the annals of laboratory science. The work of Mackaness and other investigators has demonstrated that the sensitized T lymphocyte directs the eradication of established L monocytogenes infection by elaborating soluble mediators (lymphokines), which, in turn, activate macrophages to display microbicidal effects. References 1. Real FX, Gold JW, Krown SE, et al: Listeria monocytogenes bacteremia in the acquired immunodeficiency syndrome. Ann Intern Med 1984;101:883.Crossref 2. Mackaness GB: The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med 1969;129: 973-992.Crossref 3. Simon HB, Sheagren JN: Cellular immunity in vitro: I. Immunologically mediated enhancement of macrophage bactericidal capacity. J Exp Med 1971;133:1377-1389.Crossref 4. Nieman RE, Lorber B: Listeriosis in adults: A changing pattern: Report of eight cases and review of the literature: 1968-1978. Rev Infect Dis 1980;2:207-226.Crossref 5. Armstrong D: Listeria monocytogenes , in Mandell GL, Douglas RG, Bennett JE (eds): Principles and Practice of Infectious Diseases , ed 2. New York, John Wiley & Sons Inc, 1985, pp 1177-1180. 6. Jungi TW, Gill TJ, Kunz HW, et al: Genetic control of cell-mediated immunity in the rat. J Immunogenetics 1982;9:445-456.Crossref 7. Fahey JL: Immunologic alterations, in Gottlieb MS (moderator): The acquired immunodeficiency syndrome. Ann Intern Med 1983;99:208-220.Crossref 8. Newborg MR, North RJ: On the mechanism of T cell independent anti-Listeria resistance in nude mice. J Immunol 1980;124: 571-576. 9. Czuprynski CJ, Campbell PA, Henson PM: Killing of Listeria monocytogenes by human neutrophils and monocytes, but not by monocyte-derived macrophages. J Reticuloendothel Soc 1983; 34:29-44. 10. Murray HW, Gellene RA, Libby DM, et al: Activation of tissue macrophages from AIDS patients: In vitro response of AIDS alveolar macrophages to lymphokines and interferon-gamma. J Immunol 1985;135:2374-2377. 11. Kaufmann S, Hahn H, Berger R, et al: Interferon-gamma production by Listeria monocytogenes-specific T cells active in cellular antibacterial immunity. Eur J Immunol 1983;13:265-268.Crossref 12. Murray HW, Rubin BY, Masur H, et al: Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndrome. N Engl J Med 1984;310:883-886.Crossref 13. Murray HW, Welte K, Jacobs JL, et al: Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome. J Clin Invest 1985;76:1959-1964.Crossref
TI - Why Is Listeria monocytogenes Not a Pathogen in the Acquired Immunodeficiency Syndrome?
JF - Archives of Internal Medicine
DO - 10.1001/archinte.1986.00360190063006
DA - 1986-07-01
UR - https://www.deepdyve.com/lp/american-medical-association/why-is-listeria-monocytogenes-not-a-pathogen-in-the-acquired-JDHuvvf5Ew
SP - 1299
EP - 1300
VL - 146
IS - 7
DP - DeepDyve
ER -