TY - JOUR
AU - Segura, Tatiana
AB - Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.
TI - Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge
JF - Nature Communications
DO - 10.1038/s41467-021-25383-z
DA - 2021-09-16
UR - https://www.deepdyve.com/lp/springer-journals/point-of-care-antimicrobial-coating-protects-orthopaedic-implants-from-JBlSVT28Dl
VL - 12
IS - 1
DP - DeepDyve
ER -