TY - JOUR
AU - Mair, William
AB -  During the early stages of tumorigenesis, cancerous cells undergo rapid and uncontrolled cell division as they invade the surrounding tissue. How tumors create space around them to accomplish this invasion is not well understood. A recent study showed that cancerous cells in fruit flies manage this feat by inducing neighboring cells to spontaneously destroy themselves and then filling the vacated space left behind in a process known as cell competition. In this issue of PLoS Biology , Yoichiro Tamori et al. provide evidence that this battle also occurs in mammalian tissues and uncover what determines the winners and losers when cells compete. 10.1371/journal.pbio.1000423.g001 Mahjong-defective cells (green) are out-competed by the adjacent normal cells and become apoptotic (red) both in Drosophila imaginal epithelia (left panel) and mammalian cultured epithelial cells (right panel). Cancers occur when cells undergo a process known as transformation, during which they stop replicating in a controlled manner, leading to unchecked proliferation and tumor formation. The switch from tightly regulated cell division to cancerous growth commonly results from genetic mutations, which are either inherited or acquired through chance mutagenic events or exposure to a carcinogen. Such mutations can turn off genes that usually function as tumor 
TI - How Normal Cells Can Win the Battle for Survival Against Cancer Cells
JF - PLoS Biology
DO - 10.1371/journal.pbio.1000423
DA - 2010-07-01
UR - https://www.deepdyve.com/lp/pubmed-central/how-normal-cells-can-win-the-battle-for-survival-against-cancer-cells-J0sopEFTQ4
VL - 8
IS - 7
DP - DeepDyve
ER -