TY - JOUR
AU - CAVALIERI, RALPH, R.
AB - Abstract Hypophysectomy of rats affects the rate of thyroglobulin synthesis less than its rate of proteolysis. After hypophysectomy the amount of thyroglobulin protein per thyroid gland increases continually and the average iodine concentration of thyroglobulin decreases, indicating that thyroglobulin formed after hypophysectomy is less highly iodinated than the pre-existing iodoprotein which it dilutes. Thyroglobulin of hypophysectomized rats, compared to that of intact rats, when exposed to alkali exhibits an increased susceptibility to disaggregation into 12S subunits which is consistent with its lower degree of iodination. In addition, the data suggest that thyroid glands of both intact and hypophysectomized rats contain thyroglobulin molecules with a spectrum of iodine concentrations and that, in each case, when exposed to alkali, the more lightly iodinated molecules disaggregate into subunits. Thus, the iodine concentration of 12S material formed by alkaline dialysis of thyroglobulin of intact and hypophysectomized rats was less than that of residual 19S. (Endocrinology89: 439, 1971) This content is only available as a PDF. Author notes 1 A preliminary report of this work was presented at the Meeting of the American Thyroid Association, Chicago, November 1969. 2 Supported in part by a grant from the NIH, USPHS (AM 05645), and a University of California Faculty Research Grant. 3 Supported in part by a grant from the NIH USPHS (AM 08410). Copyright © 1971 by The Endocrine Society
TI - Studies of Thyroglobulin of Hypophysectomized Rats. III. Evidence for Formation and Accumulation of Thyroglobulin Following Hypophysectomy. Relationship of Iodine Content of Thyroglobulin and Sensitivity to Disaggregation in Alkali
JO - Endocrinology
DO - 10.1210/endo-89-2-439
DA - 1971-08-01
UR - https://www.deepdyve.com/lp/oxford-university-press/studies-of-thyroglobulin-of-hypophysectomized-rats-iii-evidence-for-IZfPlK9fmQ
SP - 439
EP - 444
VL - 89
IS - 2
DP - DeepDyve
ER -