TY - JOUR
AU1 - Quinn, M K
AU2 - Williams, Paige L
AU3 - Muhihi, Alfa
AU4 - Duggan, Christopher P
AU5 - Ulenga, Nzovu
AU6 - Alwy Al-Beity, Fadhlun M
AU7 - Perumal, Nandita
AU8 - Aboud, Said
AU9 - Fawzi, Wafaie W
AU1 - Manji, Karim P
AU1 - Sudfeld, Christopher R
AB - BackgroundCombination antiretroviral therapy (cART) initiation during pregnancy reduces the risk of perinatal human immunodeficiency virus (HIV) transmission; however, studies have suggested that there may be unintended adverse consequences on birth outcomes for selected cART regimens.MethodsWe analyzed adverse birth outcomes among a prospective cohort of 1307 pregnant women with HIV in Dar es Salaam who initiated cART during the first or second trimester of a singleton pregnancy. Our primary analysis compared birth outcomes by gestational age at cART initiation among these women initiating cART in pregnancy.ResultsAmong women who initiated cART in pregnancy, there was no relationship of gestational age at cART initiation with the risk of fetal death or stillbirth. However, women who initiated cART before 20 weeks of gestation compared with after 20 weeks had increased risk of preterm birth (risk ratio [RR], 1.30; 95% confidence interval [CI], 1.03–1.67) but decreased risk of small-for-gestational age birth (RR, 0.71; 95% CI, .55–.93).ConclusionsWith increasing use of cART preconception and early in pregnancy, clinicians should be aware of the benefits and potential risks of cART regimens to optimize birth outcomes.
TI - Timing of Antiretroviral Therapy
JF - Journal of Infectious Diseases
DO - 10.1093/infdis/jiac224
DA - 2022-06-09
UR - https://www.deepdyve.com/lp/oxford-university-press/timing-of-antiretroviral-therapy-IXsD4xaOO5
SP - 687
EP - 695
VL - 226
IS - 4
DP - DeepDyve
ER -