TY - JOUR
AU - Ohnishi, Haruo
AB - Summary Urokinase (UK) preparations, obtained at random on the commercial market from ten manufacturers, were investigated for their degree of purification by measurement of their coagulant activity, lysozyme activity, kinin‐ and brady‐kinin‐like activity, endotoxin content and hepatitis B surface antigen (HBs antigen). The results indicated that the UK preparations could be divided into two groups: ‘clean’ UK which contained no detectable biologically active substances, and ‘dirty’ UK which contained abundant biological active substances. When ‘dirty’ UK containing high procoagulant activity was injected into rabbits, the coagulation system was activated. Separation of the pro‐coagulant activity from the UK components may be difficult on an industrial scale by gel filtration. Since ‘clean’ UK contains no detectable biologically active substances, its specific activity was the highest among the UK preparations.
TI - CONTAMINATING SUBSTANCES IN UROKINASE PREPARATIONS
JF - Journal of Clinical Pharmacy & Therapeutics
DO - 10.1111/j.1365-2710.1979.tb00154.x
DA - 1979-12-01
UR - https://www.deepdyve.com/lp/wiley/contaminating-substances-in-urokinase-preparations-IXZ4KwmRsU
SP - 179
VL - 4
IS - 4
DP - DeepDyve
ER -