TY - JOUR AU - POPE, C. G. AB - ANTITOXINS C. G. Pope & Yersin (1888), played most important roles. Behring & Kitasato (1890, December 4) and Behring (1890, December 11) showed that the sera of animals immunized to diphtheria or to tetanus toxins contained substances capable of neutralizing these toxins. Behring (1890) applied the name "antitoxins" to the sera from immune animals, and later (Behring, 1893) DEVELOPMENT OF KNOWLEDGE OF he stated that he carried out the original work himself, using diphtheria toxin, and subsequent work on tetanus toxin with ANTITOXINS Kitasato. Fraenkel (1890, December 3) also reported work on the production of immunity to diphtheria toxin. In 1891, diphtheria antitoxin prepared in sheep was first C. G. POPE D.Sc. used for treatment in a Berlin clinic and in the years 1891-94 The Wellcome Research Laboratories about 20,000 children were treated (Parish & Cannon, 1961). {Biological Division) The production of large amounts of antitoxic sera, using Langley Court, Beckenham, Kent horses, was first described by Roux & Martin (1894). They also described their methods for the production of toxin, immunization of horses and testing the sera on small animals. 1 Definition of antitoxins 2 The discovery of antitoxins The commercial production of antitoxin commenced in 3 Active TI - DEVELOPMENT OF KNOWLEDGE OF ANTITOXINS JO - British Medical Bulletin DO - 10.1093/oxfordjournals.bmb.a070062 DA - 1963-09-01 UR - https://www.deepdyve.com/lp/oxford-university-press/development-of-knowledge-of-antitoxins-IJSyIn50o1 SP - 230 EP - 234 VL - 19 IS - 3 DP - DeepDyve ER -