TY - JOUR
AU - Sadashiva, M. P.
AB - In an attempt to develop synergetic, potential and selective anti-oxidant agents, a series of novel piperazine bridged pseudo-peptidic urea/thiourea derivatives (5a-x) are designed by molecular docking study, synthesized and evaluated for their in-vitro anti-oxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and dimethyl-4-phenylenediamine (DMPD) methods. The results revealed that compounds 5q, 5s, 5w and 5x are good anti-oxidant agents. Amongst, compounds with aromatic side chain, thioureal fragment with electron donating group-substitution, particularly, 5s and 5w are the most active members exhibiting remarkable anti-oxidant property. The docking results are complementary to the experimental results. The correlation study revealed that compounds derived from phenylalanine and tryptophan containing electron donating group are excellent antioxidants.Graphical Abstract[graphic not available: see fulltext]
TI - Multi-pharmacophore Approach to Bio-therapeutics: Piperazine Bridged Pseudo-peptidic Urea/Thiourea Derivatives as Anti-oxidant Agents
JF - International Journal of Peptide Research and Therapeutics
DO - 10.1007/s10989-019-09824-4
DA - 2020-03-25
UR - https://www.deepdyve.com/lp/springer-journals/multi-pharmacophore-approach-to-bio-therapeutics-piperazine-bridged-IHe1vhElas
SP - 151
EP - 158
VL - 26
IS - 1
DP - DeepDyve
ER -