TY - JOUR
AU - Duara, Ranjan
AB - Objective: To determine the conversion rates to dementia in patients diagnosed with mild cognitive impairment (MCI) thought to be caused by incipient Alzheimer’s disease (MCI-AD) or with MCI with features of vascular disease (MCI-Vas). Methods: On the basis of patient history, neurocognitive, neurological and MRI evaluation, 99 patients were diagnosed with MCI-AD and 35 with MCI-Vas. Conversion to dementia over an average of a 2.4 ± 1.8-year period was determined. Results: Over the follow-up period, 44% converted to dementia, 51.5% remained classified as MCI, and 4.5% were reclassified as cognitively normal. The conversion rate to dementia was significantly faster at 3 years for the MCI-AD (50.5%) than for the MCI-Vas group (25.7%). The neuropsychological test found to best differentiate converters from non-converters was the Fuld-OME, a measure of learning and recall. Age, education, gender or APOE Ε4 allele frequency did not differentiate converters from non-converters. Conclusions: MCI-AD and MCI-Vas are clinically meaningful subtypes of MCI that may convert to dementia at different rates. Prospective studies on larger subsets of MCI patients are required to confirm these findings.
TI - Conversion to Dementia among Two Groups with Cognitive Impairment
JO - Dementia and Geriatric Cognitive Disorders
DO - 10.1159/000080124
DA - 2004-10-01
UR - https://www.deepdyve.com/lp/karger/conversion-to-dementia-among-two-groups-with-cognitive-impairment-I2KHrvELQV
SP - 307
EP - 313
VL - 18
IS - 3-4
DP - DeepDyve
ER -