TY - JOUR
AU - Potagas, Constantin
AB - BackgroundNumerous cross-sectional studies report cognitive impairment in multiple sclerosis (MS), but longitudinal studies with sufficiently long-term follow-up are scarce.ObjectiveWe aimed to investigate the cognitive 10-year course of a cohort of MS patients.Methods59 patients with clinically isolated syndrome (CIS) or relapsing–remitting (RR) MS were evaluated with Rao’s Brief Repeatable Battery of Neuropsychological Tests at baseline and follow-up (at least 10 years later). They constituted 47.2% of 124 consecutive CIS and RRMS patients originally evaluated at baseline. Patients assessed at follow-up were well matched for baseline clinical characteristics with dropouts.ResultsThe proportion of MS patients with overall cognitive impairment was increased by 10% within the 10-year period. When grouped on the basis of impairment in specific cognitive domains at baseline, patients originally impaired showed improvement at follow-up, while the opposite trend was observed for patients non-impaired at first assessment. A detailed case-by-case investigation revealed mixed evolution patterns, several patients fail in fewer domains at follow-up compared to baseline or failing at different domains at follow-up compared to baseline.ConclusionsThis study suggests a more fluid picture for the evolution of cognitive function in a subgroup of MS patients and contradicts the concept of an inevitable, progressively evolving “dementia”.
TI - A longitudinal study of cognitive function in multiple sclerosis: is decline inevitable?
JF - Journal of Neurology
DO - 10.1007/s00415-020-09720-8
DA - 2020-05-01
UR - https://www.deepdyve.com/lp/springer-journals/a-longitudinal-study-of-cognitive-function-in-multiple-sclerosis-is-Hv0rWBczhA
SP - 1464
EP - 1475
VL - 267
IS - 5
DP - DeepDyve
ER -