TY - JOUR
AU1 - Clarke, Bart L
AU2 - Amin, Shreyasee
AB - P r a c t i c e P o i n t www.nature.com/clinicalpractice/endmet Does the use of proton-pump inhibitors increase the risk of fracture? Original article Yang Y et al. (2006) Long-term proton follow-up. The primary study was conducted pump inhibitor therapy and risk of hip fracture. JAMA 296: with PPI users (some of whom took both PPIs 2947–2953 and H RAs) and controls. A secondary study was conducted with H RA users and controls. S Y n o P S i S 2 The risk of hip fracture associated with acid- Keo wy rs d BMd , hip fracture, histamine-2-receptor suppressant use was assessed as well as the antagonist, proton-pump inhibitor influence of duration of acid-suppressant use BACKGROUND (up to 4 years) on risk of hip fracture. Acid suppression with proton-pump inhibitor (PPI) therapy might lead to calcium malabsorption OUTCOME MEASURE and reduced BMD. The main outcome measure was the risk of hip fracture associated with PPI therapy. OBJECTIVE To determine whether patients on long-term PPI RESULTS therapy have an increased risk of bone fractures. In total, 13,356 patients with hip fracture and 135,386 controls were included. Mean age for DESIGN AND INTERVENTION both groups was 77±9.3 
TI - Does the use of proton-pump inhibitors increase the risk of fracture?
JF - Nature Reviews Endocrinology
DO - 10.1038/ncpendmet0556
DA - 2007-06-12
UR - https://www.deepdyve.com/lp/springer-journals/does-the-use-of-proton-pump-inhibitors-increase-the-risk-of-fracture-HkGL2LCNro
SP - 564
EP - 565
VL - 3
IS - 8
DP - DeepDyve
ER -