TY - JOUR
AU - Moore, Josiah J.
AB - THE ACTION OF VACCINES AND OF CONCENTRATED ANTI STREPTOCOCCUS SERUM IN EXPERI­ MENTAL STREPTOCOCCAL ARTHRITIS * J 0 S I A H J. Moo R E (From the Otho S. A. Sprague Memorial Institute, and the Pathological Laboratory of St. Luke's Hospital, Chicago, Ill.) EXPERIMENTS WITH CONCENTRATED ANTISTREPTOCOCCUS SERUM Antistreptococcus serum has been employed for therapeutic pur­ poses for several years without altogether satisfactory results. Since there is frequently evidence of the presence in such sera of antibodies, it is possible that low potency may be an important factor in explain­ ing the unsatisfactory results. For this reason it was thought advis­ able to make some experiments with concentrated serum. In the preparation of the serum, part of which was done by Dr. L. C. Gatewood, fifty-two strains of streptococci, including viridans and hemolyticus, as well as strains from cases of epidemic sore throat, were injected into horses. The strains were isolated from patients having tonsillitis alone or complicated with acute or chronic arthritis, endocarditis, serositis, nephritis and pyorrhea. The virulence of many strains were tested on rabbits; thirty-four produced acute or chronic arthritis in these animals. Four horses were used,1 three being injected with a mixture of various 
TI - The Action of Vaccines and of Concentrated Antistreptococcus Serum in Experimental Streptococcal Arthritis
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/15.1.215
DA - 1914-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-action-of-vaccines-and-of-concentrated-antistreptococcus-serum-in-Hc8IaTSDn7
SP - 215
EP - 226
VL - 15
IS - 1
DP - DeepDyve
ER -