TY - JOUR
AU - Gale, Robert Peter
AB - Abstract Eukaryotic cells contain a family of genes termed “cellular oncogenes” or “proto-oncogenes,” thought to regulate normal cell growth and development. In some circumstances, such as following transduction by retroviruses, activation of these genes causes tumors and leukemias in animals. Possible mechanisms of cellular oncogene activation include: 1) DNA point mutation, deletion or insertion, 2) gene amplification, 3) gene activation by internal rearrangement, chromosomal translocation or promoter insertion, 4) recombinative events resulting in the formation of novel chimeric genes, and others. In this review, we consider data which implicates cellular oncogene activation in the pathogenesis of leukemia in humans. We discuss possible mechanisms by which oncogene activation may induce leukemias, as well as potential diagnostic and therapeutic implications. Oncogenes, Chromosome, Leukemia, Translocation References 1 DeFeo-Jones D , Tatchell K, Robinson LC, et al. 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TI - Oncogenes and human leukemias
JF - Stem Cells
DO - 10.1002/stem.5530060103
DA - 1988-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/oncogenes-and-human-leukemias-Hc0IqLT0M0
SP - 2
EP - 24
VL - 6
IS - 1
DP - DeepDyve
ER -