TY - JOUR
AU - Spizizen, John
AB - BIOCHEMICAL STUDIES ON THE PHENOMENON OF VIRUS REPRODUCTION II. STUDIES ON THE INFLUENCE OF COMPOUNDS OF METABOLIC SIGNIFICANCE ON THE MULTIPLICATION OF BACTERIOPHAGE JOHN SPIZIZEN From The William G. Kerckhoff Laboratories of the Biological Sciences, California Institute of Technology, Pasadena, California. The dependence of the process of general technic were the same as those virus multiplication on the intact cell used in the previous paper. Coenzyme I suggests a rather close association of the and adenosine triphosphate were pre­ process with certain fundamental cellu­ pared by Dr. N. H. Horowitz, phytic lar reactions. This is further confirmed acid and sodium phytate by H. Lanz, by the fact that under ordinary condi­ and a-ketoglutaric acid by W. Baum-: tions active cellular growth is necessary garten-all of this laboratory. All other for virus multiplication. In order to compounds were obtained as highly identify the cellular reactions involved purified commercial preparations and in virus reproduction, the present recrystallized when necessary. studies were instituted. As far as is EXPERIMENTS known, no studies of this type have so far been made. Inhibition of phage multiplication with In the first paper of this series,' it was sulfonamides and the role of p-amino shown that in 
TI - Biochemical Studies on the Phenomenon of Virus Reproduction
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/73.3.222
DA - 1943-11-01
UR - https://www.deepdyve.com/lp/oxford-university-press/biochemical-studies-on-the-phenomenon-of-virus-reproduction-HM1t0Ye13c
SP - 222
EP - 228
VL - 73
IS - 3
DP - DeepDyve
ER -