TY - JOUR
AU - Mitsuhashi,, Susumu
AB - Abstract BO-1165 has excellent antibacterial activity against Gram-negative bacteria but it is almost inactive against Gram-positive and anaerobic bacteria. BO-1165 was more active than the four reference drugs against Escherichia coli, Salmonella spp., Shigella spp., Klebsiella pneumoniae, Serratia marcescens, indole-positive and indole-negative Proteus. Also, BO-1165 exhibited high antibacterial activity against strains of Pseudomonas aeruginosa (MIC50, 3.12 mg/l) and P. cepacia (MIC50, 1.56 mg/l), but did not against Ps. maltophilia strains. BO-1165 had good stability to plasmid-mediated and chromosome-mediated β-lactamases. However, the compound was slightly hydrolyzed by the β-lactamases isolated from Proteus vulgaris, Ps. cepacia, Klebsiella oxytoca and Ps. maltophilia, which were capable of hydrolyzing aztreonam. This content is only available as a PDF. © 1986 The British Society for Antimicrobial Chemotherapy
TI - In-vitro antibacterial activity of BO-1165, a new monobactam antibiotic
JF - Journal of Antimicrobial Chemotherapy
DO - 10.1093/jac/17.6.747
DA - 1986-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/in-vitro-antibacterial-activity-of-bo-1165-a-new-monobactam-antibiotic-HGfJt0EB1U
SP - 747
EP - 753
VL - 17
IS - 6
DP - DeepDyve
ER -