TY - JOUR
AU1 - Huang, Wen-Ying
AU2 - Yeh, Chia-Lin
AU3 - Lin, Jui-Hsiang
AU4 - Yang, Jai-Sing
AU5 - Ko, Tse-Hao
AU6 - Lin, Yu-Hsin
AB - This work developed a novel bi-layer wound dressing composed of 3D activated carbon fibers that allows facilitates fibroblast cell growth and migration to a wound site for tissue reconstruction, and the gentamicin is incorporated into a poly(γ-glutamic acid)/gelatin membrane to prevent bacterial infection. In an in vitro, field emission scanning electron microscopy shows that rat skin fibroblasts appeared and spread on the surface of activated carbon fibers, and penetrated the interior and exterior of the 3D activated carbon fiber construct to a depth of roughly 200 μm. An in vivo analysis shows that fibroblast cells containing the proposed 3D scaffold had the potential of a biologically functionalized dressing to accelerate wound closure. Additionally, fibroblasts migrated to the wound site in a bi-layer wound dressing containing fibroblasts, enhancing fibronectin and type I collagen expression, resulting in faster skin regeneration than that achieved with a Tegaderm™ hydrocolloid dressing or gauze.
TI - Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing
JF - Journal of Materials Science: Materials in Medicine
DO - 10.1007/s10856-012-4608-4
DA - 2012-03-14
UR - https://www.deepdyve.com/lp/springer-journals/development-of-fibroblast-culture-in-three-dimensional-activated-H3OQ5Z6Pnp
SP - 1465
EP - 1478
VL - 23
IS - 6
DP - DeepDyve
ER -