TY - JOUR
AU - Orr, N.A.
AB - 248 Correspondence is regarded as different from an itch, but more likely, I suspect, is that freedom to rub the skin produces pleasure of such intensity that the patient is loth to be deprived of it. Craigallion, ALAN LYEIX Skclmorlie, Ayrshire PA175DT SIR, Recently Ryatt et al. {British Journal of Dermatology 1982, 107, 71) have reported on the bio-availability of betamethasone-17-valerate (Betnovate^) ointment when diluted in emulsifying ointment and have related decreases in vasoconstrictor efficiency to its interconversion to betametha- sone-2i-valeraie. Our investigations into the stability of Betnovate' ointment and various dilutions of it using similar H.P.L.C. techniques and microscopy have revealed data which supplement their findings. It appears that appreciable changes have been made to the formulation of Betnovate* ointment without public announcement and that material obtained from the manufacturers after 1981 is significantly di^ferent in structure and physical behaviour from previously supplied ointment. In the 'old' formulation the betamethasone-17-valerate was dissolved in a mobile liquid, tentatively identified as propylene glyeolj and dispersed as droplets in a hydrocarbon base. Aliquots of ointment removed as gently as possible from tubes were found to have an acceptable uniformity of drug distribution. However, due to sampling disturbance and analytical method a 
TI - Dilution of betamethasone ointment
JF - British Journal of Dermatology
DO - 10.1111/j.1365-2133.1983.tb00070.x
DA - 1983-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/dilution-of-betamethasone-ointment-Gk0HiZ6qq6
SP - 248
EP - 250
VL - 108
IS - 2
DP - DeepDyve
ER -