TY - JOUR
AU - Roe, Catherine M.
AB - We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181], tau/Aβ42, and ptau181/Aβ42) of Alzheimer’s disease pathology to predict driving decline among cognitively-normal older adults (N = 116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ42, tau/Aβ42, ptau181/Aβ42) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.
TI - Neuropsychiatric Symptoms and Alzheimer’s Disease Biomarkers Predict Driving Decline: Brief Report
JF - Journal of Alzheimer's Disease
DO - 10.3233/jad-170067
DA - 2017-06-05
UR - https://www.deepdyve.com/lp/ios-press/neuropsychiatric-symptoms-and-alzheimer-s-disease-biomarkers-predict-GQCug2dmUn
SP - 675
EP - 680
VL - 58
IS - 3
DP - DeepDyve
ER -