TY - JOUR
AB - Acta Padiatr Scand [Suppl] 377: 78, 1991 M. Ranke (Tubingen, Germany): Was it possible to restore the insulin-like growth factor (IGF) bioactivity by removal ofiGF-binding protein 1 (IGFBP-1)? D. Dunger (Oxford, UK): We have not done any experiments to remove IGFBP-1, but we have added it, thereby increasing inhibitory activity. G. Werther (Melbourne, Australia): Is there any evidence for the suggestion that an elevated IGFBP-1 level contributes to the elevated GH level by reduced IGF-1 bioactivity? Free IGF-1 levels in the circulation are very low and most of the IGF-1 is bound to IGFBP-3. Is it known what happens at the level of the pituitary with respect to feedback? D. Dunger: It is mostly speculation. In other cell systems, IGFBP-1 is inhibitory, and it is reasonable to assume that the same may be true for the pituitary receptor. H. Fide/eff (Buenos Aires, Argentina): You compared the nocturnal growth hormone (GH) profiles of normal and diabetic adolescents. Profiles in normal boys are known to show wide variations from one night to another. Does the same phenomenon occur in diabetic children? D. Dunger: We have obtained many profiles in normal and diabetic adolescents. The timing of the GH pulses is remarkably 
TI - Discussion
JO - Acta Paediatrica: Nurturing The Child
DO - 10.1111/apa.1991.80.s377.78
DA - 1991-08-01
UR - https://www.deepdyve.com/lp/wiley/discussion-GNrridMaVg
SP - 78
EP - 78
VL - 80
IS - 
DP - DeepDyve
ER -