TY - JOUR
AU - Kaestner, Klaus H.
AB - 3564 Abstracts Translational Highlights from MOLECULAR ENDOCRINOLOGY J Clin Endocrinol Metab, July 2010, 95(7):3563–3564 A New Role for GPR103b in the Peripheral Regulation of Adipogenesis Mukandila Mulumba, Christian Jossart, Riccarda Granata, Davide Gallo, Emanuel Escher, Ezio Ghigo, Marc J. Servant, Sylvie Marleau, and Huy Ong (Mol Endocrinol, published June 9, 2010, 10.1210/me.2010-0010) ABSTRACT The activation of G protein-coupled receptor 103 (GPR103) by its endogenous peptidic ligands, QRFPs, is involved in the central regulation of feeding by increasing food intake, body weight, and fat mass after intracerebroventricular injection in mice. However, the role of GPR103 in regulating peripheral metabolic pathways has not yet been explored. The present study aimed to investigate the role of GPR103 in adipogenesis and lipid metabolism using 3T3-L1 adipocyte cells. Our results show that differentiated 3T3-L1 cells expressed the GPR103b subtype mRNA and protein, as well as QRFP mRNA. QRFP-43 and 
26 induced an increase in triglyceride accumulation of 50 and 41%, respectively, and elicited a dose-dependent increase in fatty acid uptake, by up to approximately 60% at the highest concentration, in 3T3-L1-differentiated cells. QRFP-43 and
26 inhibited isoproterenol (ISO)-induced lipolysis in a dose-dependent manner, with IC sof2.3 1.2 and 1.1 1.0 nM, respectively. The expression of 
TI - Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jcem.95.7.9996
DA - 2010-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/foxa1-and-foxa2-maintain-the-metabolic-and-secretory-features-of-the-GKNlxVToDe
SP - 3564
EP - 3564
VL - 95
IS - 7
DP - DeepDyve
ER -