TY - JOUR
AU - Sacks, David, B
AB - The measurement of hemoglobin A1c (Hb A1c)2 is integral to the management of patients with diabetes. Hb A1c is used in the evaluation of long-term (8–12 weeks) glucose control, to alter therapy and predict the risk for development of microvascular complications, and as a criterion to diagnose diabetes. Early Hb A1c assays measured different forms of glycohemoglobin and lacked standardization. The publication of the Diabetes Control and Complications Trial (DCCT) in 1993 motivated the development of standardization programs in Japan, Sweden, and the US. The National Glycohemoglobin Standardization Program (official name later shortened to the acronym NGSP) was by far the most widely implemented program around the world, being used in the vast majority of countries that had Hb A1c standardization. The subsequent development of a reference measurement system by the IFCC led to several meetings to effect universal standardization of Hb A1c. At the initial meeting in 2004, participants reached consensus for the adoption of the IFCC reference method as the global standard for calibration of Hb A1c assays. All participants agreed that the same Hb A1c values should be reported globally. These decisions were endorsed at subsequent meetings in 2007 and 2009. Additional recommendations, published in 2010 in Clinical Chemistry (1), were: Hb A1c results should be reported by clinical laboratories worldwide in Système International (SI) units (mmol/mol, no decimals) and derived NGSP units (%, 1 decimal), using the IFCC–NGSP master equation (DCCT units). Hb A1c conversion tables including both SI (IFCC) and NGSP units should be easily accessible to the diabetes community. Editors of journals were strongly recommended to require that submitted manuscripts report Hb A1c in both SI (IFCC) and NGSP/DCCT units. The most recent meeting was held in December 2011 in Dubai. The objective of the deliberation was to evaluate the progress of implementation of the prior recommendations. Unfortunately, the goal of reporting the same units worldwide has not been realized. Dual reporting has been adopted by very few countries and has been transitory for the vast majority of these countries. Some countries have elected to report only SI units, while other countries have decided to maintain NGSP/DCCT units. Notwithstanding these developments, the meeting attendees recommended that both SI (IFCC) and NGSP/DCCT units be used for reporting Hb A1c in journals and other printed materials. To facilitate this goal, calculators to convert between millimoles per mole and percentage have been made available (http://www.hba1c.nu/eng2.html and http://www.ngsp.org/convert1.asp). Several journals have adopted this policy and all journals are encouraged to do so. Meeting Participants American Diabetes Association: Sue Kirkman and Matt Petersen. European Association for the Study of Diabetes: Viktor Joergens and Andrew Boulton. International Diabetes Federation: Jean-Claude Mbanya and Stephen Colagiuri. IFCC: Garry John and Graham Beastall. International Society for Pediatrics and Adolescent Diabetes: Ragnar Hanas and Lynda Fisher. Japanese Diabetes Society: Izumi Takei. NGSP: David Sacks. 2 Nonstandard abbreviations: Hb A1c hemoglobin A1c DCCT Diabetes Control and Complications Trial NGSP National Glycohemoglobin Standardization Program SI Système International. " Author Contributions:All authors confirmed they have contributed to the intellectual content of this paper and have met the following 3 requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; and (c) final approval of the published article. " Authors' Disclosures or Potential Conflicts of Interest:Upon manuscript submission, all authors completed the author disclosure form. Disclosures and/or potential conflicts of interest: " Employment or Leadership: D.B. Sacks, Clinical Chemistry, AACC. " Consultant or Advisory Role: None declared. " Stock Ownership: None declared. " Honoraria: None declared. " Research Funding: D.B. Sacks, NIH. " Expert Testimony: None declared. " Patents: None declared. Acknowledgments Work in the author's laboratory is funded by the Intramural Research Program of the National Institutes of Health. Reference 1. Hanas R , John G; International HbA(1c) Consensus Committee . 2010 Consensus statement on the worldwide standardization of the hemoglobin A1c measurement . Clin Chem 2010 ; 56 : 1362 – 4 . Google Scholar Crossref Search ADS PubMed WorldCat © 2013 The American Association for Clinical Chemistry This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - 2011 Consensus Meeting on the Worldwide Standardization of Hemoglobin A1c Measurement
JF - Clinical Chemistry
DO - 10.1373/clinchem.2013.204800
DA - 2013-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/2011-consensus-meeting-on-the-worldwide-standardization-of-hemoglobin-GDwV8fqYJy
SP - 857
VL - 59
IS - 5
DP - DeepDyve
ER -