TY - JOUR
AU - Aboushleib, H.M.
AB - IntroductionDespite the great efforts made to improve the diagnosis, prevention and treatment, tuberculosis (TB) remains a major global health problem, especially in developing countries. It is considered to be one of the top ten causes of death worldwide, ranking above the human immunodeficiency virus (HIV) as one of the leading causes of death from an infectious disease. The World Health Organization (WHO) estimates that approx. 10·4 million new TB cases occur worldwide and about 1·4 million individuals die of TB every year (WHO ). Among the different reasons, it is believed that diagnostic inaccuracy and/or delays, vaccine failure and drug resistance are the main contributors to the current TB epidemic (Young et al. ). Therefore, a critical step in the control of TB is the early and accurate diagnosis of infection.The standard approach for diagnosis of pulmonary TB involves the detection of Mycobacterium tuberculosis (MTB) in sputum by microscopy and/or by microbiological culture. Although it is limited by its low sensitivity, sputum smear microscopy remains the most widely used method for the simple and rapid detection of acid‐fast bacilli and is almost the only test available in resource‐limited settings. Furthermore, culture methods require a well‐established laboratory and long incubation times of 
TI - Mycothiol acetyltransferase (Rv0819) of Mycobacterium tuberculosis is a potential biomarker for direct diagnosis of tuberculosis using patient serum specimens
JO - Letters in Applied Microbiology
DO - 10.1111/lam.12801
DA - 2017-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/mycothiol-acetyltransferase-rv0819-of-mycobacterium-tuberculosis-is-a-G6UFSULhvx
SP - 504
EP - 511
VL - 65
IS - 6
DP - DeepDyve
ER -