TY - JOUR
AU - Kovalev, I.
AB - MOLECULAR-BIOLOGICAL PROBLEMS IN THE SEARCH FOR, PRODUCTION OF, AND MECHANISM OF ACTION OF DRUGS SYNTHESIS AND CHARACTERISTICS OF CONJUGATED CAFFEINE--PROTEIN ANTIGENS O. Yu. Polevaya, N. P. Danilova, UDC 547.857.4'963.2+615.373 E. R. Rubtsova, and I. E. Kovalev During the last few years, studies on the synthesis of conjugated antigens -- biologically active compounds covalently bonded to proteins -- have been intensively conducted. These preparations are used for the production of antibodies for biologically active compounds. Such antibodies are capable of neutralizing the pharmacological action of drugs [1-3]. Anti- bodies are also used for the quantitative determination of drugs in organs and tissues by the highly sensitive radioimmune method [4, 5]. Recently the possibility of using proteins for the directed transport of biologically active compounds covalently bonded to them into definite cells has been demonstrated [6-8]. The purpose of this investigation was to develop a method of producing conjugated caffeine--protein antigens, permitting the synthesis of preparations with various caffeine contents, and an immunological characterization of these conjugates. The caffeine molecule does not contain functional groups capable of interacting with proteins under mild conditions. Therefore, we decided to synthesize 8-aminocaffeine, since it is known [9] that the diazonium salt of the latter 
TI - Synthesis and characteristics of conjugated caffeine-protein antigens
JF - Pharmaceutical Chemistry Journal
DO - 10.1007/BF01156474
DA - 2005-01-29
UR - https://www.deepdyve.com/lp/springer-journals/synthesis-and-characteristics-of-conjugated-caffeine-protein-antigens-G4YPQaJ4c4
SP - 441
EP - 447
VL - 11
IS - 4
DP - DeepDyve
ER -