TY - JOUR
AU - Vanhoutte, P.M.
AB - 172 173 Cross-Desensitization Studies with Endothelin Endothelium-Dependent Forearm Vasodilation to Isopeptides in the Rat Isolated Superior Mesenteric Acetylcholine but Not That to Substance P Is Arterial Bed Impaired in Patients with Heart Failure C.R. Hi ley, M.K.G. McStay. R E Boitrill. S.A. Douglas Yoshilaka Hirooka, Tsuiomu Imaizumi, Shinya Tagawa, Department o f Pharmacology, University o f Cambridge. UK Akira Takeshila Research Institute o f Angiocardiology and Cardiovascular The superior mesenteric arterial bed was removed from heparin­ Clinic, Faculty o f Medicine. Kyushu University, Fukuoka, ized (1.000 U kg-1) male Wistar rats (250-400 g) and perfused with Japan Krebs-Henseleit solution containing lOp.V/ indomcthacin at 2 ml min-' [Douglas SA. Hilcy CR. Br J Pharmacol 1990:101:81-88]. It has been shown that endothelium-dependent vasorelaxation to Endothelium was removed by perfusion with 0.3% w/v CHAPS after acetylcholine (ACh) is attenuated in experimental heart failure. This study aimed to determine if endothelium-dependent vasodilation which 45 min was allowed for equilibration before a ‘standard dose’ of either endothelin-1 (100 pmol). endothelin-2 (100 pmol) or endo- evoked with ACh or substance P (SP) is also attenuated in patients thclin-3 (3 nmol) was administered: these doses approximate to the with heart failure. In patients with heart failure 
TI - 2nd International Symposium on Endothelium-Derived Vasoactive Factors (Part 5 of 11)
JF - Journal of Vascular Research
DO - 10.1159/000317445
DA - 1992-01-01
UR - https://www.deepdyve.com/lp/karger/2nd-international-symposium-on-endothelium-derived-vasoactive-factors-G06x90srKL
SP - 135
EP - 149
VL - 29
IS - 2
DP - DeepDyve
ER -