TY - JOUR
AU - Ollier, William E. R.
AB - To determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus B19 infection, we compared human leukocyte antigen (HLA) class I and II alleles in 36 patients with symptomatic acute B19 infection with those in >900 control subjects from northwestern England. The frequency of each of HLA-DRB1*01 (P=.016), DRB1*04 (P=.007), and DRB1*07 (P<.0001) alleles was significantly higher in parvovirus B19 patients than in control subjects. In the parvovirus group, 63.9% carried the rheumatoid arthritis–associated shared epitope sequence, compared with 45% of control subjects (odds ratio [OR], 2.2; 95% confidence interval [CI], 0.97–4.8; P=.04), and carriage was associated with fatigue during the acute phase (OR, 4.2; 95% CI, 0.8–23.9; P=.047). All symptomatic parvovirus-associated HLA-DRB1 molecules carry a neutrally charged glutamine at position 10 and a positively charged lysine at position 12 of the first hypervariable region. HLA-B49 was associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and DRB1*07
TI - Association of Symptomatic Acute Human Parvovirus B19 Infection with Human Leukocyte Antigen Class I and II Alleles
JO - Journal of Infectious Diseases
DO - 10.1086/341947
DA - 2002-08-15
UR - https://www.deepdyve.com/lp/oxford-university-press/association-of-symptomatic-acute-human-parvovirus-b19-infection-with-FuQjFXsavR
SP - 447
EP - 452
VL - 186
IS - 4
DP - DeepDyve
ER -