TY - JOUR
AU - Hasan , , Aurangzeb
AB -  A series of 14 new bioactive 1-N-acid hydrazide substituted pyrazolines were synthesized by cyclization of variably substituted chalcones and different acid hydrazides, using acetic acid as a solvent. The chemical structure of the compounds was characterized by FTIR, EIMS and 'H NMR spectroscopy. The antibacterial activities of these compounds were evaluated by agar well diffusion method. 1-Npicolinic acid hydrazide pyrazoline was found to be more active as compared to the standard antibiotic Roxithromycin. Introduction Pyrazolines and their derivatives display various biological properties such as pesticidal, fungicidal, insecticidal, anti-inflammatory, antiarthritic, antidepressant and antiviral activities11\"31. Considerable interest has been focused on the pyrazolines structure, which has known to possess a broad spectrum of biological activities such as antinociceptive, antibacterial, antioxidant and antiamoebic [4 8). Moreover, these heterocyclic compounds, in addition to biological activities have also shown some industrial applications like bleaching agents, dyes, optical brighteners and various fluorescent whitening agents' 1 \" 3,9 \" 12) . Earlier studies by Gabriele Murineddu, et al. [13] also demonstrated the analgesic and antiinflammatory activities of acid hydrazides. The present study is therefore devoted to the synthesis of pyrazolines from variably substituted chalcones which are also associated with diverse biological activities '14\"'8) and different 
TI - SYNTHESIS OF SOME NEW BIOACTIVE 1-N-ACID HYDRAZIDE SUBSTITUTED PYRAZOLINES
JO - Heterocyclic Communications
DO - 10.1515/HC.2006.12.5.377
DA - 2006-10-01
UR - https://www.deepdyve.com/lp/de-gruyter/synthesis-of-some-new-bioactive-1-n-acid-hydrazide-substituted-FivqwNGfH0
SP - 377
VL - 12
IS - 5
DP - DeepDyve
ER -