TY - JOUR
AU - Mashaghi, Alireza
AB - IntroductionMacrophages are mechanically active immune cells involved in host pathogen interactions, cancer progression, and metastasis.[1–3] Macrophages are differentiated from blood monocytes that extravasate from blood vessels into tissues where they home and reside to orchestrate immune responses or homeostatic tissue repair including wound healing. These cells are also sensitive to the stiffness and topography of the environment[4] or strains applied to the tissues.[5–9] It has been suggested that mechanical properties of macrophages are linked to their immune function.[10–12] Macrophages are known to be highly heterogeneous, with two major polarized phenotypes, called M1 and M2, with distinct morphologies. Morphology is known to be tightly linked to cell mechanics as well. Macrophages thus remodel their mechanics and morphology during differentiation to different macrophage subtypes, a process that is primed by colony‐stimulating factors (CSFs). Alterations in the physical microenvironment often underlie pathophysiological states, and understanding of their effects on macrophage phenotype and function may help provide mechanistic insights into disease pathogenesis. As such, probing the mechanical properties of these cells could provide fundamentally important insights into their function in health and disease, and could provide novel biomarker of immune activation and disease.Single‐cell modalities such as atomic force microscopy (AFM), micropipette aspiration (MA), 
TI - Single‐Cell Mechanical Characterization of Human Macrophages
JF - Advanced Nanobiomed Research
DO - 10.1002/anbr.202100133
DA - 2022-07-01
UR - https://www.deepdyve.com/lp/wiley/single-cell-mechanical-characterization-of-human-macrophages-FenqY0xcnh
VL - 2
IS - 7
DP - DeepDyve
ER -