TY - JOUR
AU - van der Poll, Tom
AB - To obtain insight in the capacity of the lipopolysaccharide (LPS)–tolerant host to produce interferon (IFN)–γ and to respond to this cytokine, whole blood was obtained from healthy humans before and 4 h after intravenous injection of LPS (4 ng/kg) and stimulated ex vivo. LPS exposure in vivo resulted in a diminished capacity to produce IFN-γ after restimulation with LPS, together with a reduced ability to release the IFN-γ–inducing cytokines interleukin (IL)–12 and IL-18 and with reduced responsiveness toward these cytokines. In addition, IFN-γ responsiveness was strongly diminished after in vivo LPS exposure, as shown by the fact that blood obtained after LPS injection could not be primed by IFN-γ for LPS-induced tumor necrosis factor–α release and that peripheral blood monocytes could not be stimulated by IFN-γ to up-regulate major histocompatibility complex type II expression. Experimentally induced immunoparalysis is associated with strongly reduced IFN-γ production and responsiveness
TI - Diminished Interferon-γ Production and Responsiveness after Endotoxin Administration to Healthy Humans
JO - Journal of Infectious Diseases
DO - 10.1086/345675
DA - 2002-12-15
UR - https://www.deepdyve.com/lp/oxford-university-press/diminished-interferon-production-and-responsiveness-after-endotoxin-FaTOsb24mM
SP - 1748
EP - 1753
VL - 186
IS - 12
DP - DeepDyve
ER -