TY - JOUR
AU - Arisz,, L.
AB - Abstract Proteinuria in patients with glomerular disease has a circadian rhythm, but for creatinine such a rhythm is either absent or of low amplitude. We found in 18 of 23 admitted patients (group I) and in seven outpatients (group II) a marked circadian rhythm of the protein: creatinine ratio. Estimates of 24-h proteinuria were obtained by multiplying the protein:creatinine ratio of 3-h urine samples with 24-h creatinine excretion, calculated from age, sex and bodyweight. Estimated proteinuria could be as low as 19% or as high as 349% of actually measured 24-h proteinuria; the mean SD was 23%. The best estimate was obtained with the 06.00–09.00 hours urine samples. The estimates correlated better with actually measured 24-h proteinuria than the protein: creatinine ratio per se correlated with the 24-h proteinuria. Day-to-day variation of proteinuria estimates from samples taken at the same time of the day was of similar magnitude as day-to-day variation of actual 24-h proteinuria. We conclude that the usefulness of the protein:creatinine ratio of a random urine sample for estimation of proteinuria is limited, because of the circadian rhythm of proteinuria. However, samples collected at a fixed time of the day are an acceptable alternative for 24-h urine collections in the clinical follow-up of individual patients. Circadian rhythm, Proteinuria, Protein:creatinine ratio, Random sample, 24-h Urine collections This content is only available as a PDF. © 1989 European Dialysis and Transplant Association-European Renal Association
TI - Circadian Rhythm of Proteinuria: Consequences of the Use of Urinary Protein:Creatinine Ratios
JO - Nephrology Dialysis Transplantation
DO - 10.1093/oxfordjournals.ndt.a091784
DA - 1989-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/circadian-rhythm-of-proteinuria-consequences-of-the-use-of-urinary-FXS5uSR3j8
SP - 9
EP - 14
VL - 4
IS - 1
DP - DeepDyve
ER -