TY - JOUR
AU1 - Azuma, Kohei
AU2 - Yamada, Hidehiro
AU3 - Ohkubo, Michiko
AU4 - Yamasaki, Yoshioki
AU5 - Yamasaki, Masaomi
AU6 - Mizushima, Machiko
AU7 - Ozaki, Shoichi
AB - Abstract The aim of this study was to define the standardized incidence ratio (SIR) of malignancy and the potential risk factors of concomitant malignancies in patients with inflammatory myopathies, including clinically amyopathic dermatomyositis (CADM). A total of 145 patients diagnosed with either dermatomyositis/polymyositis (DM/PM) or CADM at our institute between 1984 and 2002 were enrolled in the study. The demographic, clinical and laboratory features of the patients at the time of DM/PM or CADM diagnosis were compared between patients with and without malignancies, respectively. Multivariate analysis by logistic regression was used to determine the independent risk factors for the development of malignancies in DM/PM patients. Malignancy was found in 17 of 70 patients with DM (24%), three of 15 patients with CADM (20%), and three of 51 patients with PM (6%). Gastric cancer (8/23) was the most common malignancy. Compared with general population, the SIR of malignancies was 13.8 (range 9.0–21.1). The patients who developed malignancies were older (61.5 vs. 51.1 years; P < 0.005), presented more often with dysphagia (61 vs. 15%; P < 0.0001) and were less likely to have the complication of interstitial lung disease (30 vs. 60%; P < 0.05). These features were independent predictive factors for developing malignancies in multiple logistic regression analysis. The results of our study confirm that CADM in addition to DM was associated with high rates of malignancy among our patient cohort. Polymyositis, Dermatomyositis, Amyopathic dermatomyositis, Malignancy, Risk factor References Stertz G. Polymyositis. Berl Klin Wochenschr. 1916 ; 53: 489 . Sigurgeirsson B , Lindelof B, Edhag O, Allander E. Risk of cancer in patients ith dermatomyositis or polymyositis . A population-based study. N Engl J Med . 1992 ; 326 ( 6 ): 363 – 7 . Google Scholar OpenURL Placeholder Text WorldCat Buchbinder R , Forbes A, Hall S, Dennett X, Giles G . Incidence of malignant disease in biopsy-proven inflammatory myopathy. A population-based cohort study. Ann Intern Med . 2001 ; 134 ( 12 ): 1087 – 95 . Google Scholar OpenURL Placeholder Text WorldCat el-Azhary RA , Pakzad SY. Amyopathic dermatomyositis: retro-spective review of 37 cases. J Am Acad Dermatol. 2002 ; 46 ( 4 ): 560 – 5 . Caproni M , Cardinali C, Parodi A, Giomi B, Papini M, Vaccaro M, Marzano A, De Simone C, Fazio M, Rebora A, Fabbri P . Amyopathic dermatomyositis: a review by the italian group of immunodermatology. Arch Dermatol . 2002 ; 138 ( 1 ): 23 – 7 . Google Scholar OpenURL Placeholder Text WorldCat Olsen NJ , Park JH, King LE Jr . Amyopathic dermatomyositis. Curr Rheumatol Rep . 2001 ; 3 ( 4 ): 346 – 51 . Google Scholar Crossref Search ADS WorldCat Hunger RE , Dun C, Brand CU . Cutaneous leukocytoclastic vasculitis in dermatomyositis suggests malignancy. Dermatology . 2001 ; 202 ( 2 ): 123 – 6 . Google Scholar OpenURL Placeholder Text WorldCat Fardet L , Dupuy A, Gain M, Kettaneh A, Cherin P, Bachelez H, Dubertret L, Lebbe C, Morel P, Rybojad M. Factors associated with underlying malignancy in a retrospective cohort of 121 patients with dermatomyositis . Medicine (Baltimore) . 2009 ; 88 ( 2 ): 91 – 7 . Google Scholar Crossref Search ADS PubMed WorldCat Basset-Seguin N , Roujeau JC, Gherardi R, Guillaume JC, Revuz J, Touraine R. Prognostic factors and predictive signs of malig-nancy in adult dermatomyositis. A study of 32 cases. Arch Dermatol. 1990 ; 126 ( 5 ): 633 – 7 . Bohan A , Peter JB. Polymyositis and dermatomyositis (second of two parts) . N Engl J Med . 1975 ; 292 ( 8 ): 403 – 7 . Google Scholar Crossref Search ADS PubMed WorldCat Bohan A , Peter JB. Polymyositis and dermatomyositis (first of two parts) . N Engl J Med . 1975 ; 292 ( 7 ): 344 – 7 . Google Scholar Crossref Search ADS PubMed WorldCat Sontheimer RD . Cutaneous features of classic dermatomyositis and amyopathic dermatomyositis . Curr Opin Rheumatol . 1999 ; 11 ( 6 ): 475 – 82 . Google Scholar Crossref Search ADS PubMed WorldCat Ministry of Health and Welfare of Japan . Ministry of Health and Welfare of Japan, Tokyo; 1998 . Zampieri S , Valente M, Adami N, Biral D, Ghirardello A, Rampuda ME, Vecchiato M, Sarzo G, Corbianco S, Kerm H, Carraro U, Bassetto F, Merigliano S, Doria A. Polymyositis, dermatomyositis and malignancy: a further intriguing link . Autoimmun Rev . 2010 ; 9 ( 6 ): 449 – 53 . Google Scholar Crossref Search ADS PubMed WorldCat Hill CL , Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, Evans SR, Felson DT. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study . Lancet . 2001 ; 357 ( 9250 ): 96 – 100 . Google Scholar Crossref Search ADS PubMed WorldCat Chen YJ , Wu CY, Shen JL . Predicting factors of malignancy in dermatomyositis and polymyositis: a case-control study. Br J Dermatol . 2001 ; 144 ( 4 ): 825 – 31 . Google Scholar OpenURL Placeholder Text WorldCat Huang YL , Chen YJ, Lin MW, Wu CY, Liu PC, Chen TJ, Chen YC, Jih JS, Chen CC, Lee DD, Chang YT, Wang WJ, Liu HN. Malignancies associated with dermatomyositis and polymyositis in Taiwan: a nationwide population-based study. Br J Dermatol . 2009 ; 161 : 854 – 60 . Liu W , Gao Z, Ni D, Li W, Li Y, Wang H. Dermatomyositis/ polymyositis associated with head and neck malignancy. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 ; 19 ( 8 ): 340 , 1 ,344. Hatada T , Aoki I, Ikeda H, Tamura T, Okada K, Nakai T, Utsunomiya J . Dermatomyositis and malignancy: case report and review of the Japanese literature. Tumori . 1996 ; 82 ( 3 ): 273 – 5 . Google Scholar OpenURL Placeholder Text WorldCat Stockton D , Doherty VR, Brewster DH . Risk of cancer in patients with dermatomyositis or polymyositis, and follow-up implica-tions: A Scottish population-based cohort study. Br J Cancer . 2001 ; 85 ( 1 ): 41 – 5 . Google Scholar OpenURL Placeholder Text WorldCat Dourmishev LA . Dermatomyositis associated with malignancy . 12 case reports. Adv Exp Med Biol . 1999 ; 455 : 193 – 9 . Google Scholar Crossref Search ADS WorldCat Andras C , Ponyi A, Constantin T, Csiki Z, Szekanecz E, Szod-oray P, Danko K. Dermatomyositis and polymyositis associated with malignancy: a 21-year retrospective study. J Rheumatol. 2008 ; 35 ( 3 ): 438 – 44 . Ponyi A , Constantin T, Garami M, Andras C, Tallai B, Vancsa A, Gergely L, Danko K. Cancer-associated myositis: clinical fea-tures and prognostic signs . Ann N Y Acad Sci . 2005 ; 1051 : 64 – 71 . Google Scholar Crossref Search ADS PubMed WorldCat Schnabel A , Hellmich B, Gross WL . Interstitial lung disease in polymyositis, dermatomyositis. Curr Rheumatol Rep . 2005 ; 7 ( 2 ): 99 – 105 . Google Scholar OpenURL Placeholder Text WorldCat Suda T , Fujisawa T, Enomoto N, Nakamura Y, Inui N, Naito T, Hashimoto D, Sato J, Toyoshima M, Hashizume H, Chida K . Interstitial lung diseases associated with amyopathic dermato-myositis. Eur Respir J . 2006 ; 28 ( 5 ): 1005 – 12 . Google Scholar OpenURL Placeholder Text WorldCat This content is only available as a PDF. © 2011 Japan College of Rheumatology This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) © 2011 Japan College of Rheumatology
TI - Incidence and predictive factors for malignancies in 136 Japanese patients with dermatomyositis, polymyositis and clinically amyopathic dermatomyositis
JF - Modern Rheumatology
DO - 10.3109/s10165-010-0362-y
DA - 2011-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/incidence-and-predictive-factors-for-malignancies-in-136-japanese-FN93xF8xJf
SP - 178
EP - 183
VL - 21
IS - 2
DP - DeepDyve
ER -