TY - JOUR
AU - 
AB - Cell. Mol. Life Sci. (2013) 70:1451–1467 DOI 10.1007/s00018-012-1216-x Cellular and Molecular Life Sciences RESEARCH AR TIC L E Stabilization of human interferon-a1 mRNA by its antisense RNA • • • • Tominori Kimura Shiwen Jiang Mikio Nishizawa Emi Yoshigai • • • Iwao Hashimoto Masao Nishikawa Tadayoshi Okumura Hisao Yamada Received: 18 January 2012 / Revised: 31 October 2012 / Accepted: 19 November 2012 / Published online: 8 December 2012 The Author(s) 2012. This article is published with open access at Springerlink.com Abstract Antisense transcription is a widespread phe- previously reported to function as the nuclear export ele- nomenon in the mammalian genome and is believed to play ment. Following infection of human Namalwa lymphocytes a role in regulating gene expression. However, the exact with Sendai virus or infection of guinea pig 104C1 fetal functional significance of antisense transcription is largely fibroblasts with influenza virus A/PR/8/34, expression of unknown. Here, we show that natural antisense (AS) RNA IFN-a1 AS RNA becomes elevated. This elevated expres- is an important modulator of interferon-a1 (IFN-a1) mRNA sion results in increased IFN-a1 mRNA stability because of levels. A *4-kb, spliced IFN-a1 AS RNA targets a single- the cytoplasmic (but not nuclear) interaction of 
TI - Stabilization of human interferon-α1 mRNA by its antisense RNA
JF - Cellular and Molecular Life Sciences
DO - 10.1007/s00018-012-1216-x
DA - 2012-12-08
UR - https://www.deepdyve.com/lp/unpaywall/stabilization-of-human-interferon-1-mrna-by-its-antisense-rna-FGdaDz6Fra
DP - DeepDyve
ER -