TY - JOUR
AU - Shalet, Stephen
AB - In healthy humans, growth hormone (GH) is secreted in distinct pulses with an underlying nyctohemeral pattern. Current forms of somatropin replacement are unable to closely mimic such a release pattern, but are still able to exert the beneficial action of GH. A limited number of short-term studies in rodents and humans suggest that longitudinal growth may be superior when somatropin is given with a pulsatile mode of administration, whereas hepatic insulin-like growth factor-I generation and beneficial changes in body composition appear to be equal or even enhanced with continuous somatropin administration.
TI - Prospects for the Development of Long-Acting Formulations of Human Somatropin
JF - Treatments in Endocrinology
DO - 10.2165/00024677-200605030-00002
DA - 2012-08-30
UR - https://www.deepdyve.com/lp/springer-journals/prospects-for-the-development-of-long-acting-formulations-of-human-FG8s92dEj1
SP - 139
EP - 145
VL - 5
IS - 3
DP - DeepDyve
ER -