TY - JOUR
AU - Kong, Liang
AB - INTRODUCTIONThe surface topography on biomedical implants plays a critical role in improving biomechanical fixation, implant osseointegration, and clinical success. Previous studies have shown that microstructure surfaces can promote early fixation and long‐term mechanical stability through maximizing the interlocking between the implant and surrounding bone tissue. Furthermore, nanostructure surfaces possess unique properties that influence cellular activities and alter the process of osseointegration through mechanotransduction‐mediated direct and adhesion‐related signal‐mediated indirect mechanisms. Since bone tissues are composed of nano, micro, and macroscale building blocks, it has been suggested that the formation of a hierarchical hybrid micro/nanostructure implant surface might represent a promising strategy to achieve enhanced osseointegration from the viewpoint of bionics.Recently, numerous studies regarding the positive osteogenic effects of hierarchical hybrid micro/nanostructure surfaces have been reported. For example, micropitted/nanotubular titania topographies, generated through the addition of nanotubules to a micropitted surface, selectively promoted the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs) and enhanced ultimate osseointegration compared to a micropitted surface alone. Similarly, the addition of nanostructure to a dual acid‐etched implant surface appeared to accelerate the bone formation relative to that from single dual acid‐etched implant surfaces. However, the nanotubes and the nano‐grains, each 80 nm in diameter, were 
TI - Effects of different hierarchical hybrid micro/nanostructure surfaces on implant osseointegration
JF - Clinical Implant Dentistry and Related Research
DO - 10.1111/cid.12471
DA - 2017-06-01
UR - https://www.deepdyve.com/lp/wiley/effects-of-different-hierarchical-hybrid-micro-nanostructure-surfaces-FCxw00VnRO
SP - 539
EP - 548
VL - 19
IS - 3
DP - DeepDyve
ER -