TY - JOUR
AU1 - Petersen, Eskild
AU2 - Hegh, Birthe
AU3 - Marbiah, Nuahn T.
AU4 - David, Kim
AU5 - Hanson, Aloysius P.
AB - A total of 1622 individuals of all ages living under conditions of continuous malarial transmission in Liberia were enrolled in a cross-sectional study of parasite rates, positive parasite densities, and body temperatures. The age-specific Piasmodium falciparum-positive parasite densities were greatest at ages 0.5–1.0 year, then slowly declined into adulthood. The age-specific mean body temperature at parasite isodensity showed a steady decline even in the oldest age group. The results do not support the hypothesis that adults have higher body temperatures at a given parasite density than do children with the same parasite density. The age-specific P. falciparum parasite density for specific isotemperatures showed that a subgroup of children in the age group 0.5–1.0 year had low temperatures <36.5°C) despite high parasite densities. This indicates that low body temperature should be investigated further as a possible indicator of serious malaria in young children. Parasitologic and clinical immunity develop concomitantly and cannot be separated. The findings do not support the hypothesis that a special “anti-disease” immunity exists independently of parasitologic immunity.
TI - Development of Immunity against Plasmodium falciparum Malaria: Clinical and Parasitologic Immunity Cannot Be Separated
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/164.5.949
DA - 1991-11-01
UR - https://www.deepdyve.com/lp/oxford-university-press/development-of-immunity-against-plasmodium-falciparum-malaria-clinical-EmmtnYl525
SP - 949
EP - 953
VL - 164
IS - 5
DP - DeepDyve
ER -