TY - JOUR
AU - Robinette, M, L
AB - Abstract The colorimetric reaction of cuprous iodide and disulfiram has been collaboratively studied in 8 laboratories to determine the drug in tablet form at 2 dosage levels. The disulfiram was extracted from the tablet matrix with methylene chloride. After a basic wash with 1 M NaOH, an aliquot of the methylene chloride solution was reacted with solid cuprous iodide, and the absorbance of the resulting color was measured. Single assays on 2 synthetic preparations of known disulfiram content were performed with average recoveries of 98.4 and 99.2% for 93.3 and 105.3mg, respectively. Duplicate determinations on 2 commercial tablet preparations declared at 250 and 500 mg gave mean and standard deviation values of 246.6 ± 6.40 and 493.6 ± 12.0 mg, respectively. The results agreed closely with those obtained by the author using the NF iodometric titration procedure. The method has been adopted official first action. This content is only available as a PDF. © Journal of the Association of Official Analytical Chemists This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Colorimetric Determination of Disulfiram in Tablets: Collaborative Study
JF - Journal of AOAC International
DO - 10.1093/jaoac/64.3.554
DA - 1981-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/colorimetric-determination-of-disulfiram-in-tablets-collaborative-ETXBek5cNX
SP - 554
EP - 556
VL - 64
IS - 3
DP - DeepDyve
ER -