TY - JOUR
AU - Guardia, Jaime
AB - To determine whether the abnormalities of cell-mediated immunity described in chronic D hepatitis are associated with hepatitis D virus (HDV) infection or concomitant human immunodeficiency virus (HIV) infection, serologic and tissue hepatitis B virus (HBV) and HOV markers and T lymphocyte subsets were studied in serum samples from 38p atients with chronic D hepatitis, 26 of whom had HIV infection. Patients with chronic D hepatitis and HIV infection had significantly lower peripheral blood T4:T8 ratios resulting from a significant increase in T8+ (suppressor/cytotoxic) cells, while numbers of T lymphocyte subsets were normal in cases with chronic D hepatitis only. HIV+ patients showed an increase in HBV replication (identified by hepatitis B core antigen in liver and hepatitis Be antigen and HBV DNA in serum) and in HDV replication (tissue D antigen and HDV RNA) without evidence ofmore active liver disease. Probably the immunologic disturbances detected in chronic D hepatitis are secondary to HIV infection, do not contribute to the pathogenesis of liver injury, and are associated with increased viral B and D replication.
TI - Influence of Human Immunodeficiency Virus Infection on Cell-Mediated Immunity in Chronic D Hepatitis
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/163.6.1351
DA - 1991-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/influence-of-human-immunodeficiency-virus-infection-on-cell-mediated-EK4EuvB8zR
SP - 1351
EP - 1353
VL - 163
IS - 6
DP - DeepDyve
ER -