TY - JOUR
AB -  205 [3]. Pathologically proven thymic infiltration with histiocytosis X is also rare and is not limited to children [5]. This infiltration was not associated with radiographically detected masses or calcification. In necropsy studies of the thymus in 32 children with histiocytosis X, three morphologic categories were established: dysplastic, dysmorphic, and involuted [5]. The dysplastie type (4 patients) showed loss of normal thymic architecture with lobules devoid of small lymphocytes and no significant histiocytic infiltration. Dysmorphic change, the most c o m m o n category (25patients), was characterized by loss of thymic architecture and some histiocytic infiltration. Foci of dystrophic calcification and blood vessel calcification were occasionally seen. Nonspecific thymic involution (5 patients) showed varying degrees of involution without loss of Hassall's corpuscles, thereby distinguishing involution from the other two types, which lacked Hassall's corpuscles. Twenty-seven of these 32 children who died of histiocytosis X had unusual thymic changes. It has been suggested that stress involution associated with chemotherapy may produce these thymic alterations. However, 10 of the 27 patients with the most severe dysplastic or dysmorphic changes had not had chemotherapy; therefore, it is unlikely that chemotherapy is the major factor. Our patient's thymus appeared inhomogeneous on 
TI - New books
JF - Pediatric Radiology
DO - 10.1007/BF02013836
DA - 1993-06-01
UR - https://www.deepdyve.com/lp/springer-journals/new-books-E5IbBwG73y
SP - 205
EP - 205
VL - 23
IS - 3
DP - DeepDyve
ER -