TY - JOUR
AB - Reactions 1532, p130 - 20 Dec 2014 Rhabdomyolysis secondary to lactic acidosis: case report A 52-year-old man developed rhabdomyolysis secondary to lactic acidosis while receiving lamivudine, zidovudine and iomeprol [routes not stated]. The man, who had a HIV infection, was admitted for exertional angina. He was receiving antiretroviral therapy with nucleoside reverse transcriptase inhibitors (NRTIs) lamivudine 150mg twice daily and zidovudine 300mg twice daily, since 2007. He underwent a coronary angiography with iomeprol 350 mg/mL, 110mL of isosmolar iodinated X-ray contrast medium. The following day, he developed aesthenia and muscular pain. Laboratory tests revealed an increase in myoglobin and creatine kinase (CK) levels up to 2089 ng/mL and 7611 UI/L, respectively. Rhabdomyolysis was suspected. The man received supportive management with sodium chloride solution. His creatinine was 0.78 mg/dL 2 days after administration of iomeprol. Five days after the coronary angiography, his symptoms resolved with normalisation of the laboratory parameters. An electromyography revealed a myogenic pattern. An ischaemic forearm exercise test was compatible with mitochondrial dysfunction. Author comment: "We describe a case of temporal association between rhabdomyolysis and administration of [iomeprol] suggesting a causal relationship." "This damage conceivably may have been secondary to mitochondrial dysfunction caused by NRTIs." "The notable 
TI - Iomeprol/lamivudine/zidovudine
JF - Reactions Weekly
DO - 10.1007/s40278-014-5941-9
DA - 2014-12-20
UR - https://www.deepdyve.com/lp/springer-journals/iomeprol-lamivudine-zidovudine-DhoWcrr4hE
SP - 130
EP - 130
VL - 1532
IS - 1
DP - DeepDyve
ER -