TY - JOUR
AU - Costigan, D, C
AB - Abstract Insulin-like growth factor 1 (IGF 1) concentrations in mixed saliva samples, collected from a normal population (n = 327, ranging in age from birth to adolescence), were determined by RIA. Salivary IGF 1 concentrations remained steady over a 24-h period when collected at basal rates, but were diminished in saliva samples collected at a maximally stimulated flow rate. A similar pattern was observed for males and females, when IGF 1 levels in saliva were plotted as a function of age. The pattern was that of low levels in early childhood, rising with age, peaking in puberty and falling again in late adolescence. Salivary IGF 1 measurement differed from plasma measurement in three ways: 1) salivary IGF 1 concentrations (70 +/- 50 pM) were 100- to 200-fold less than plasma IGF 1 levels; 2) salivary IGF 1 levels in age-matched male and female samples were not different outside of pubertal influences; 3) salivary IGF 1 levels in neonates were highly variable with concentrations ranging up to pubertal concentrations. The study provides salivary IGF 1 reference data for a pediatric population. This content is only available as a PDF. Copyright © 1992 by The Endocrine Society
TI - A normal population study of human salivary insulin-like growth factor 1 (IGF 1) concentrations from birth through puberty
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jcem.74.4.1548339
DA - 1992-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/a-normal-population-study-of-human-salivary-insulin-like-growth-factor-DaGHSFMui0
SP - 774
EP - 778
VL - 74
IS - 4
DP - DeepDyve
ER -