TY - JOUR AU - Batra, Vineeta AB - Pediatr Nephrol (2017) 32:1355–1361 DOI 10.1007/s00467-017-3613-8 ORIGINAL ARTICLE Toll-like receptor 3 (TLR-3), TLR-4 and CD80 expression in peripheral blood mononuclear cells and urinary CD80 levels in children with idiopathic nephrotic syndrome 1 1 2 3 Om P. Mishra & Ravindra Kumar & Gopeshwar Narayan & Pradeep Srivastava & 1 1 1 4 Abhishek Abhinay & Rajniti Prasad & Ankur Singh & Vineeta V. Batra Received: 5 July 2016 /Revised: 9 January 2017 /Accepted: 16 January 2017 /Published online: 16 February 2017 IPNA 2017 Abstract urinary CD80/creatinine values were significantly higher in Background The aims of this study were (1) to detect toll-like patients with SSNS and SRNS than in the controls and receptor (TLR)-3, TLR-4 and CD80 expression in peripheral steroid-sensitive patients in remission (p < 0.001). CD80 blood mononuclear cells (PBMCs) and estimate urinary CD80 levels were also significantly higher in patients with MCD levels in children with idiopathic nephrotic syndrome and (2) than in those with FSGS (p = 0.002). A cut-off level of to investigate the utility of these markers to differentiate be- >914.5 ng/g had a sensitivity of 86.6%, specificity 71.4% tween biopsy-proven minimal change disease (MCD) and fo- and area under the curve of TI - Toll-like receptor 3 (TLR-3), TLR-4 and CD80 expression in peripheral blood mononuclear cells and urinary CD80 levels in children with idiopathic nephrotic syndrome JF - Pediatric Nephrology DO - 10.1007/s00467-017-3613-8 DA - 2017-02-16 UR - https://www.deepdyve.com/lp/springer-journals/toll-like-receptor-3-tlr-3-tlr-4-and-cd80-expression-in-peripheral-D9AxAWHwYr SP - 1355 EP - 1361 VL - 32 IS - 8 DP - DeepDyve ER -