TY - JOUR
AU1 - Wouw, Heidi L.
AU2 - Yen, Shuo‐Ting
AU3 - Valet, Manon
AU4 - Garcia, Joseph A.
AU5 - Gomez, Carlos O.
AU6 - Vian, Antoine
AU7 - Liu, Yucen
AU8 - Pollock, Jennifer
AU9 - Pospíšil, Petr
AU1 - Campàs, Otger
AU1 - Sletten, Ellen M.
AB - Fluorocarbon oils are uniquely suited for many biomedical applications due to their inert, bioorthogonal properties. In order to interface fluorocarbon oils with biological systems, non‐ionic fluorosurfactants are necessary. However, there is a paucity of non‐ionic fluorosurfactants with low interfacial tension (IFT) to stabilize fluorocarbon phases in aqueous environments (such as oil‐in‐water emulsions). We developed non‐ionic fluorosurfactants composed of a polyethylene glycol (PEG) segment covalently bonded to a flexible perfluoropolyether (PFPE) segment that confer low IFTs between a fluorocarbon oil (HFE‐7700) and water. The synthesis of a panel of surfactants spanning a molecular weight range of 0.64–66 kDa with various hydrophilic‐lipophilic balances allowed for identification of minimal IFTs, ranging from 1.4 to 17.8 mN m−1. The majority of these custom fluorosurfactants display poor solubility in water, allowing their co‐introduction with fluorocarbon oils and minimal leaching. We applied the PEG5PFPE1 surfactant for mechanical force measurements in zebrafish, enabling exceptional sensitivity.
TI - Non‐Ionic Fluorosurfactants for Droplet‐Based in vivo Applications
JF - Angewandte Chemie
DO - 10.1002/ange.202404956
DA - 2024-12-20
UR - https://www.deepdyve.com/lp/wiley/non-ionic-fluorosurfactants-for-droplet-based-in-vivo-applications-D0WyjdJeFF
VL - 136
IS - 52
DP - DeepDyve
ER -