TY - JOUR
AU1 - Muftuoglu, Ilkay
AU2 - Lin, Tiezhu
AU3 - Freeman, William
AB - Purpose Automated segmentation of retinal layers by spectral-domain optical coherence tomography (SD-OCT) is usually erroneous in the presence of retinal diseases. The purpose of this study is to report the changes in ganglion cell complex (GCC) comprising retina nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) in neovascular age-related macular degeneration (AMD) patients by manually correcting the automated segmentation errors. Methods Thirty eyes of 30 patients with new-onset choroidal neovascularization secondary to neovascular AMD and 30 eyes of 30 healthy subjects were included. The inner retinal thicknesses were measured using early treatment diabetic retinopathy circle in the central 1 mm (fovea) and surrounding 3 mm diameter (parafovea) after checking the accuracy of automated segmentation lines. Manual segmentation was done to ensure the accurate segmentation, when needed. Results Neovascular AMD patients had thicker mean RNFL, GCL, IPL, and GCC thicknesses within the fovea compared to healthy eyes (p =0.04, p =0.001, p =0.032, and p = 0.005, respectively). In the parafoveal area, among the thickness-related measurements, the only significant difference was a thicker mean RNFL (p =0.002). Conclusion Diffuse thickening of inner retinal layers in neovascular AMD may overestimate actual GCC thickness within fovea. This 
TI - Inner retinal thickening in newly diagnosed choroidal neovascularization
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
DO - 10.1007/s00417-018-4093-7
DA - 2018-08-09
UR - https://www.deepdyve.com/lp/springer-journals/inner-retinal-thickening-in-newly-diagnosed-choroidal-D0OwUA8NfL
SP - 2035
EP - 2040
VL - 256
IS - 11
DP - DeepDyve
ER -