TY - JOUR
AU1 - Kobayashi-Sakamoto, Michiyo
AU2 - Tamai, Riyoko
AU3 - Kiyoura, Yusuke
AU4 - 
AB - Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) receptor superfamily, suppresses osteoclast formation by preventing the binding of receptor activator of nuclear factor-kappa B ligand (RANKL) to receptor activator of NF-kappa B (RANK). Recent studies indicate that RANKL plays a critical role in the regulation of dendritic cells and macrophages. Indeed, RANK-RANKL interactions on these immune cells are involved in core host defense mechanisms against tumors and infection. Thus, OPG is thought to exert its effects by interfering with the RANKL-RANK interaction. While the role of OPG in bone metabolism are well described, little is known about its role in host defense. This review summarizes current knowledge about the role of OPG in pathologies such as cancer and microbial infections. Introduction OPG prevents the RANKL-induced die ff rentiation, fu - sion, and activation of osteoclasts Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor superfamily, originally characterized according to its Osteoclasts are multinucleated bone resorbing cells formed by ability to suppress osteoclast formation by preventing the binding cytoplasmic fusion of their mononuclear precursors, which belong of receptor activator of nuclear factor-kappa B ligand (RANKL) to to the myeloid lineage of hematopoietic cells that also 
TI - Beyond bone remodeling–emerging functions of osteoprotegerin in host defense and microbial infection
JF - Integrative Molecular Medicine
DO - 10.15761/imm.1000173
DA - 2015-01-01
UR - https://www.deepdyve.com/lp/unpaywall/beyond-bone-remodeling-emerging-functions-of-osteoprotegerin-in-host-ColsDq9Ci1
DP - DeepDyve
ER -