TY - JOUR
AU - Pickett, M. J.
AB - THE JOURNAL OF INFECTIOUS DISEASES • VOL. 122, NO.6' DECEMBER 1970 © 1970 by the University of Chicago. All rights reserved. Vibrio choleruet Production of Toxin by a Nonpathogenic Strain From the Department of Bacteriology, Uzy Blachman, S. Basu, * and M. J. Pickett University of California, Los Angeles, California Vaccines presently employed do not provide ade­ either choleragenic toxin or toxoid is produced by these water vibrios. If toxin is indeed produced quate protection against cholera [1] despite the by these "nonpathogenic" vibrios, then this be­ fact that high titers of humoral agglutinating and comes an important parameter in consideration of vibriocidal antibody are produced. Intestinal im­ such strains as potential oral vaccines. We have, munity is now believed to be of major significance therefore, sought evidence that one such strain in control of the disease. Several investigators is toxigenic. have explored the ability of heat-killed [2] and live nonpathogenic [3] oral vaccines to stimulate local immunity. There are arguments for their Materials and Methods effectiveness; Freter found coproantibodies in 77 % of orally vaccinated human volunteers but Strains. V. cholerae strain 569B Inaba was in only 47% of those vaccinated parenterally [2]. obtained from N. K. Dutta; 
TI - Vibrio cholerae: Production of Toxin by a Nonpathogenic Strain
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/122.6.540
DA - 1970-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/vibrio-cholerae-production-of-toxin-by-a-nonpathogenic-strain-ChCU4UE0tc
SP - 540
EP - 543
VL - 122
IS - 6
DP - DeepDyve
ER -