TY - JOUR
AU - Chang,, Feng-Yee
AB - Abstract The effect of cefodizime on the function in vitro of neutrophils from poorly-controlled, non-insulin-dependent diabetics was demonstrated by the chemotactic index and by chemiluminescence. Without cefodizime treatment, the chemotactic index for diabetic neutrophils was significantly lower than that for healthy controls (1.0±0.1 vs 3.6±0.7; mean±S.E.M., P>0.01). When neutrophils were pretreated with cefodizime at 1 or 10 mg/l, cefodizime restored the chemotactic activity of diabetic neutrophils (1.0±0.1 vs 2.7±0.3, P>0.01), but did not affect the activity in healthy controls. Conversely, cefodizime at 100 mg/l had no enhancing effect on diabetic neutrophil chemotaxis, but decreased the chemotactic activity of healthy neutrophils (1.1±0.2 vs 3.6±0.7, P>0.01). A difference in neutrophil chemiluminescence was also found between diabetics and healthy subjects but no influence of cefodizime on chemiluminescence was noted in neutrophils from either diabetics or healthy subjects. This content is only available as a PDF. © 1990 by The British Society for Antimicrobial Chemotherapy
TI - Influence of cefodizime on chemotaxis and the respiratory burst in neutrophils from diabetics
JO - Journal of Antimicrobial Chemotherapy
DO - 10.1093/jac/26.1.55
DA - 1990-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/influence-of-cefodizime-on-chemotaxis-and-the-respiratory-burst-in-CbdTX7L0Fc
SP - 55
EP - 59
VL - 26
IS - 1
DP - DeepDyve
ER -