TY - JOUR
AU - Simpkins,, Henry
AB - Case Description A 74-year-old woman with toxic nodular goiter, diabetes mellitus, depression, gastroesophageal reflux disease, and hypercholesterolemia had routine serum protein electrophoresis done for the first time. Her medications included metformin, levothyroxine, sertraline, rosuvastatin, and rabeprazole. The patient's renal function was normal. Serum protein electrophoresis was carried out by capillary electrophoresis (CAPILLARYS™; Sebia Electrophoresis). Immunofixation electrophoresis revealed no monoclonal immunoglobulin bands. Protein electrophoresis of the patient's serum sample. Fig. 1. Open in new tabDownload slide Ref int, reference interval; Conc, concentration. Fig. 1. Open in new tabDownload slide Ref int, reference interval; Conc, concentration. Questions What is unusual about the electrophoretic pattern? What is responsible for this anomaly? The answers are on the next page. Answers The albumin peak is split; this phenomenon is known as bisalbuminemia or alloalbuminemia. Bisalbuminemia is usually caused by an albumin variant that differs from the most common allotype, albumin A, by a single amino acid residue, thereby producing 2 albumin fractions of equal or unequal amounts. Inherited forms are usually discovered incidentally. The acquired form has been associated with multiple myeloma, chronic renal failure, pancreatitis, and use of cephalosporins and β-lactam antibiotics. Bisalbuminemia is better visualized with capillary electrophoresis. " Author Contributions:All authors confirmed they have contributed to the intellectual content of this paper and have met the following 3 requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; and (c) final approval of the published article. " Authors' Disclosures or Potential Conflicts of Interest:No authors declared any potential conflicts of interest. © 2013 The American Association for Clinical Chemistry This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Is This Pathological?
JF - Clinical Chemistry
DO - 10.1373/clinchem.2012.191916
DA - 2013-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/is-this-pathological-CSmPa9vVGG
SP - 448
VL - 59
IS - 2
DP - DeepDyve
ER -