TY - JOUR AU - H. Suzuki and C. M. Ferrario AB - fluid SUZUKI, HIROMICHI, AND CARLOS M. FERRARIO. New method for collection of cerebrospinal fluid from the of conscious dogs. Am. J. Physiol. 246 (Heart Circ. Physiol. 15): H551-H558,1984.-We have developed a catheter system that can be implanted chronically into the of the dog to obtain serial samples of cerebrospinal fluid (CSF) for up to 8 wk. A direct accessto the CSF of the provided an opportunity to determine also base-line values of CSF sodium, potassium, norepinephrine, epinephrine, and angiotensin II immunoreactivity and compare relative differences in the concentration of these variables between the central and peripheral compartments. neurotransmitters; angiotensin II; unanesthetized dogs; arterial pressure; norepinephrine; arterial hypertension; sodium chloride; neuropeptides SERIAL SAMPLING of cerebrospinal fluid (CSF) over periods of days or weeks can provide important insights into the role of specific transmitter and neuropeptides in the regulation of brain function. Since we were interested in determining whether alterations in the CSF content of sodium (Na+), norepinephrine, and angiotensin II are a part of the changes associated with the development of experimental hypertension, we investigated what techniques were available to accomplish this aim. Although several systems are described (1, 20, 29, 31), few permitted investigation in unanesthetized animals. Several TI - New method for the collection of cerebrospinal fluid from the cisterna magna of conscious dogs JF - AJP - Heart and Circulatory Physiology DA - 1984-04-01 UR - https://www.deepdyve.com/lp/the-american-physiological-society/new-method-for-the-collection-of-cerebrospinal-fluid-from-the-cisterna-CNKTmWAgLJ VL - 246 IS - DP - DeepDyve ER -